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Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin
Tyrosyl-DNA phosphodiesterase I (TDP1) hydrolyzes the drug-stabilized 3’phospho-tyrosyl bond formed between DNA topoisomerase I (TOPO1) and DNA. TDP1-mediated hydrolysis uses a nucleophilic histidine (His(nuc)) and a general acid/base histidine (His(gab)). A Tdp1His(gab) to Arg mutant identified in...
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| Publié dans: | Oncotarget |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Impact Journals LLC
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5349943/ https://ncbi.nlm.nih.gov/pubmed/27893431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13528 |
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