Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin

Tyrosyl-DNA phosphodiesterase I (TDP1) hydrolyzes the drug-stabilized 3’phospho-tyrosyl bond formed between DNA topoisomerase I (TOPO1) and DNA. TDP1-mediated hydrolysis uses a nucleophilic histidine (His(nuc)) and a general acid/base histidine (His(gab)). A Tdp1His(gab) to Arg mutant identified in...

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Udgivet i:Oncotarget
Main Authors: Cuya, Selma M., Comeaux, Evan Q., Wanzeck, Keith, Yoon, Karina J., van Waardenburg, Robert C.A.M.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349943/
https://ncbi.nlm.nih.gov/pubmed/27893431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13528
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