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Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts

Our genomic DNA is under constant assault from endogenous and exogenous sources, which needs to be resolved to maintain cellular homeostasis. The eukaryotic DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1) catalyzes the hydrolysis of phosphodiester bonds that covalently link adducts to DNA-e...

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Detalhes bibliográficos
Publicado no:Cancer Drug Resist
Principais autores: Brettrager, Evan J., van Waardenburg, Robert C.A.M.
Formato: Artigo
Idioma:Inglês
Publicado em: OAE Publishing Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929713/
https://ncbi.nlm.nih.gov/pubmed/31875206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20517/cdr.2019.91
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