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Enhanced Generation of Intraluminal Vesicles in Neuronal Late Endosomes in the Brain of a Down Syndrome Mouse Model with Endosomal Dysfunction

Down syndrome (DS) is a human genetic disease caused by trisomy of chromosome 21 and characterized by early developmental brain abnormalities. Dysfunctional endosomal pathway in neurons is an early event of DS and Alzheimer’s disease. Recently, we have demonstrated that exosome secretion is upregula...

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Detalhes bibliográficos
Publicado no:Dev Neurobiol
Main Authors: D’Acunzo, Pasquale, Hargash, Tal, Pawlik, Monika, Goulbourne, Chris N., Pérez-González, Rocío, Levy, Efrat
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894426/
https://ncbi.nlm.nih.gov/pubmed/31278881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dneu.22708
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