Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

A dysfunctional endosomal pathway and abnormally enlarged early endosomes in neurons are an early characteristic of Down syndrome (DS) and Alzheimer’s disease (AD). We have hypothesized that endosomal material can be released by endosomal multivesicular bodies (MVBs) into the extracellular space via...

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Библиографические подробности
Опубликовано в: :Acta Neuropathol Commun
Главные авторы: Gauthier, Sébastien A., Pérez-González, Rocío, Sharma, Ajay, Huang, Fang-Ke, Alldred, Melissa J., Pawlik, Monika, Kaur, Gurjinder, Ginsberg, Stephen D., Neubert, Thomas A., Levy, Efrat
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2017
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576289/
https://ncbi.nlm.nih.gov/pubmed/28851452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0466-0
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