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A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients
Down syndrome (DS) is characterized by cognitive deficits throughout the lifespan and with the development of aging-dependent Alzheimer’s type neuropathology, which is related to the triplication of the amyloid β precursor protein (APP) gene. A dysfunctional endosomal system in neurons is an early c...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Neurobiol Aging |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6960325/ https://ncbi.nlm.nih.gov/pubmed/31479861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2019.07.016 |
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