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Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein

Recent data suggest that intraneuronal accumulation of metabolites of the amyloid β precursor protein (APP) is neurotoxic. We observed that transgenic mice overexpressing in neurons a human APP gene harboring the APP(E693Q) (Dutch) mutation have intraneuronal lysosomal accumulation of APP carboxyl-t...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Psychiatry
Egile Nagusiak: Kaur, Gurjinder, Pawlik, Monika, Gandy, Sam E., Ehrlich, Michelle E., Smiley, John F., Levy, Efrat
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405008/
https://ncbi.nlm.nih.gov/pubmed/27777419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.189
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