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Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein
Recent data suggest that intraneuronal accumulation of metabolites of the amyloid β precursor protein (APP) is neurotoxic. We observed that transgenic mice overexpressing in neurons a human APP gene harboring the APP(E693Q) (Dutch) mutation have intraneuronal lysosomal accumulation of APP carboxyl-t...
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| Publicado no: | Mol Psychiatry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5405008/ https://ncbi.nlm.nih.gov/pubmed/27777419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.189 |
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