A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients

Down syndrome (DS) is characterized by cognitive deficits throughout the lifespan and with the development of aging-dependent Alzheimer’s type neuropathology, which is related to the triplication of the amyloid β precursor protein (APP) gene. A dysfunctional endosomal system in neurons is an early c...

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Bibliographic Details
Published in:Neurobiol Aging
Main Authors: Pérez-González, Rocío, Gauthier, Sébastien A., Sharma, Ajay, Miller, Chelsea, Pawlik, Monika, Kaur, Gurjinder, Kim, Yohan, Levy, Efrat
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960325/
https://ncbi.nlm.nih.gov/pubmed/31479861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2019.07.016
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