Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function

BACKGROUND: Regulatory T (T(reg)) cells have an immunosuppressive function in cancer, but the underlying mechanism of immunosuppression in the tumor microenvironment (TME) is unclear. METHODS: We compared the phenotypes of T cell subsets, including T(reg) cells, obtained from peripheral blood, malig...

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Détails bibliographiques
Publié dans:J Immunother Cancer
Auteurs principaux: Kim, Hye Ryun, Park, Hyo Jin, Son, Jimin, Lee, Jin Gu, Chung, Kyung Young, Cho, Nam Hoon, Shim, Hyo Sup, Park, Seyeon, Kim, Gamin, In Yoon, Hong, Kim, Hyun Gyung, Jung, Yong Woo, Cho, Byoung Chul, Park, Seong Yong, Rha, Sun Young, Ha, Sang-Jun
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894345/
https://ncbi.nlm.nih.gov/pubmed/31801611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0785-8
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