Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function

BACKGROUND: Regulatory T (T(reg)) cells have an immunosuppressive function in cancer, but the underlying mechanism of immunosuppression in the tumor microenvironment (TME) is unclear. METHODS: We compared the phenotypes of T cell subsets, including T(reg) cells, obtained from peripheral blood, malig...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Kim, Hye Ryun, Park, Hyo Jin, Son, Jimin, Lee, Jin Gu, Chung, Kyung Young, Cho, Nam Hoon, Shim, Hyo Sup, Park, Seyeon, Kim, Gamin, In Yoon, Hong, Kim, Hyun Gyung, Jung, Yong Woo, Cho, Byoung Chul, Park, Seong Yong, Rha, Sun Young, Ha, Sang-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894345/
https://ncbi.nlm.nih.gov/pubmed/31801611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0785-8
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