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IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α–regulated pseudohypoxic state
The role of mitochondria in cancer continues to be debated and paradoxically implicated in opposing functions in tumor growth and tumor suppression. To understand this dichotomy, we explored the function of mitochondrial isocitrate dehydrogenase (IDH)2, a tricarboxylic acid cycle enzyme mutated in s...
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| Pubblicato in: | FASEB J |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Federation of American Societies for Experimental Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6894043/ https://ncbi.nlm.nih.gov/pubmed/31530011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901366R |
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