MITOCHONDRIAL Akt REGULATION OF HYPOXIC TUMOR REPROGRAMMING

Hypoxia is a universal driver of aggressive tumor behavior, but the underlying mechanisms are not completely understood. Using a phosphoproteomics screen, we now show that active Akt accumulates in the mitochondria during hypoxia and phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) on Thr346 to...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Chae, Young Chan, Vaira, Valentina, Caino, M. Cecilia, Tang, Hsin-Yao, Seo, Jae Ho, Kossenkov, Andrew V., Ottobrini, Luisa, Martelli, Cristina, Lucignani, Giovanni, Bertolini, Irene, Locatelli, Marco, Bryant, Kelly G., Ghosh, Jagadish C., Lisanti, Sofia, Ku, Bonsu, Bosari, Silvano, Languino, Lucia R., Speicher, David W., Altieri, Dario C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131882/
https://ncbi.nlm.nih.gov/pubmed/27505672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.07.004
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