The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells

Mitochondria are signaling hubs in eukaryotic cells. Here, we showed that the mitochondrial FUN14-domain-containing protein-1 (FUNDC1), an effector of Parkin-independent mitophagy, also participates in cellular plasticity by sustaining oxidative bioenergetics, buffering ROS production and supporting...

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Bibliografske podrobnosti
izdano v:Sci Signal
Main Authors: Li, Jie, Agarwal, Ekta, Bertolini, Irene, Seo, Jae Ho, Caino, M. Cecilia, Ghosh, Jagadish C., Kossenkov, Andrew V., Liu, Qin, Tang, Hsin-Yao, Goldman, Aaron R., Languino, Lucia R., Speicher, David W., Altieri, Dario C.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484983/
https://ncbi.nlm.nih.gov/pubmed/32723812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaz8240
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