AKT PHOSPHORYLATION OF MITOCHONDRIAL LonP1 PROTEASE ENABLES OXIDATIVE METABOLISM AND ADVANCED TUMOR TRAITS

Tumor mitochondria have heightened protein folding quality control, but the regulators of this process and how they impact cancer traits are not completely understood. Here we show that the ATP-directed mitochondrial protease, LonP1 is upregulated by stress conditions, including hypoxia, in tumor, b...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Ghosh, Jagadish C., Seo, Jae Ho, Agarwal, Ekta, Wang, Yuan, Kossenkov, Andrew V., Tang, Hsin-Yao, Speicher, David W., Altieri, Dario C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814529/
https://ncbi.nlm.nih.gov/pubmed/31406245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0939-7
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