AKT PHOSPHORYLATION OF MITOCHONDRIAL LonP1 PROTEASE ENABLES OXIDATIVE METABOLISM AND ADVANCED TUMOR TRAITS

Tumor mitochondria have heightened protein folding quality control, but the regulators of this process and how they impact cancer traits are not completely understood. Here we show that the ATP-directed mitochondrial protease, LonP1 is upregulated by stress conditions, including hypoxia, in tumor, b...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Ghosh, Jagadish C., Seo, Jae Ho, Agarwal, Ekta, Wang, Yuan, Kossenkov, Andrew V., Tang, Hsin-Yao, Speicher, David W., Altieri, Dario C.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814529/
https://ncbi.nlm.nih.gov/pubmed/31406245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0939-7
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