Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

BACKGROUND: Small molecule inhibitors of phosphatidylinositol-3 kinase (PI3K) have been developed as molecular therapy for cancer, but their efficacy in the clinic is modest, hampered by resistance mechanisms. METHODS: We studied the effect of PI3K therapy in patient-derived tumor organotypic cultur...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Ghosh, Jagadish C., Siegelin, Markus D., Vaira, Valentina, Faversani, Alice, Tavecchio, Michele, Chae, Young Chan, Lisanti, Sofia, Rampini, Paolo, Giroda, Massimo, Caino, M. Cecilia, Seo, Jae Ho, Kossenkov, Andrew V., Michalek, Ryan D., Schultz, David C., Bosari, Silvano, Languino, Lucia R., Altieri, Dario C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565533/
https://ncbi.nlm.nih.gov/pubmed/25650317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju502
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