Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

BACKGROUND: Small molecule inhibitors of phosphatidylinositol-3 kinase (PI3K) have been developed as molecular therapy for cancer, but their efficacy in the clinic is modest, hampered by resistance mechanisms. METHODS: We studied the effect of PI3K therapy in patient-derived tumor organotypic cultur...

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Udgivet i:J Natl Cancer Inst
Main Authors: Ghosh, Jagadish C., Siegelin, Markus D., Vaira, Valentina, Faversani, Alice, Tavecchio, Michele, Chae, Young Chan, Lisanti, Sofia, Rampini, Paolo, Giroda, Massimo, Caino, M. Cecilia, Seo, Jae Ho, Kossenkov, Andrew V., Michalek, Ryan D., Schultz, David C., Bosari, Silvano, Languino, Lucia R., Altieri, Dario C.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565533/
https://ncbi.nlm.nih.gov/pubmed/25650317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju502
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