CONTROL OF TUMOR BIOENERGETICS AND SURVIVAL STRESS SIGNALING BY MITOCHONDRIAL HSP90s

Tumors successfully adapt to constantly changing intra- and extra-cellular environments, but the wirings of this process are still largely elusive. Here, we show that Heat Shock Protein 90 (HSP90)-directed protein folding in mitochondria, but not cytosol, maintains energy production in tumor cells....

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Autors principals: Chae, Young Chan, Caino, M. Cecilia, Lisanti, Sofia, Ghosh, Jagadish C., Dohi, Takehiko, Danial, Nika N., Villanueva, Jessie, Ferrero, Stefano, Vaira, Valentina, Santambrogio, Luigi, Bosari, Silvano, Languino, Lucia R., Herlyn, Meenhard, Altieri, Dario C.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615709/
https://ncbi.nlm.nih.gov/pubmed/22975376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.07.015
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