LANDSCAPE OF THE MITOCHONDRIAL Hsp90 METABOLOME IN TUMORS

Reprogramming of tumor cell metabolism contributes to disease progression and resistance to therapy, but how this process is regulated on the molecular level is unclear. Here we report that Heat Shock Protein 90 (Hsp90)-directed protein folding in mitochondria controls central metabolic networks in...

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Autors principals: Chae, Young Chan, Angelin, Alessia, Lisanti, Sofia, Kossenkov, Andrew A., Speicher, Kaye D., Wang, Huan, Powers, James F., Tischler, Arthur S., Pacak, Karel, Fliedner, Stephanie, Michalek, Ryan D., Karoly, Edward D., Wallace, Douglas C., Languino, Lucia R., Speicher, David W., Altieri, Dario C.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732457/
https://ncbi.nlm.nih.gov/pubmed/23842546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3139
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