DELETION OF THE MITOCHONDRIAL CHAPERONE TRAP-1 UNCOVERS GLOBAL REPROGRAMMING OF METABOLIC NETWORKS

Reprogramming of metabolic pathways contributes to human disease, especially cancer, but the regulators of this process are unknown. Here, we generated mice knockout for the mitochondrial chaperone TRAP-1, a regulator of bioenergetics in tumors. TRAP-1(−/−) mice are viable and showed reduced inciden...

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Detalhes bibliográficos
Main Authors: Lisanti, Sofia, Tavecchio, Michele, Chae, Young Chan, Liu, Qin, Brice, Angela K., Thakur, Madhukar L., Languino, Lucia R., Altieri, Dario C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127146/
https://ncbi.nlm.nih.gov/pubmed/25088416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.061
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