Cytoprotective Mitochondrial Chaperone TRAP-1 As a Novel Molecular Target in Localized and Metastatic Prostate Cancer

Molecular chaperones of the heat shock protein-90 (Hsp90) family promote cell survival, but the molecular requirements of this pathway in tumor progression are not understood. Here, we show that a mitochondria-localized Hsp90 chaperone, tumor necrosis factor receptor-associated protein-1 (TRAP-1), i...

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Autors principals: Leav, Irwin, Plescia, Janet, Goel, Hira Lal, Li, Jing, Jiang, Zhong, Cohen, Ronald J., Languino, Lucia R., Altieri, Dario C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2010
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797899/
https://ncbi.nlm.nih.gov/pubmed/19948822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090521
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