Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development

Protein homeostasis, or proteostasis, is required for mitochondrial function, but its role in cancer is controversial. Here we show that transgenic mice expressing the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) in the prostate develop epithelial hyperplasia and cellular atypia. When e...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Lisanti, Sofia, Garlick, David S., Bryant, Kelly G., Tavecchio, Michele, Mills, Gordon B., Lu, Yiling, Kossenkov, Andrew V., Showe, Louise C., Languino, Lucia R., Altieri, Dario C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122790/
https://ncbi.nlm.nih.gov/pubmed/27754870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745950
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