PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

Molecular therapies are hallmarks of “personalized” medicine, but how tumors adapt to these agents is not well-understood. Here we show that small-molecule inhibitors of phosphatidylinositol 3-kinase (PI3K) currently in the clinic induce global transcriptional reprogramming in tumors, with activatio...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Caino, M. Cecilia, Ghosh, Jagadish C., Chae, Young Chan, Vaira, Valentina, Rivadeneira, Dayana B., Faversani, Alice, Rampini, Paolo, Kossenkov, Andrew V., Aird, Katherine M., Zhang, Rugang, Webster, Marie R., Weeraratna, Ashani T., Bosari, Silvano, Languino, Lucia R., Altieri, Dario C.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507184/
https://ncbi.nlm.nih.gov/pubmed/26124089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500722112
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