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PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
Molecular therapies are hallmarks of “personalized” medicine, but how tumors adapt to these agents is not well-understood. Here we show that small-molecule inhibitors of phosphatidylinositol 3-kinase (PI3K) currently in the clinic induce global transcriptional reprogramming in tumors, with activatio...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4507184/ https://ncbi.nlm.nih.gov/pubmed/26124089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500722112 |
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