PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

Molecular therapies are hallmarks of “personalized” medicine, but how tumors adapt to these agents is not well-understood. Here we show that small-molecule inhibitors of phosphatidylinositol 3-kinase (PI3K) currently in the clinic induce global transcriptional reprogramming in tumors, with activatio...

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保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Caino, M. Cecilia, Ghosh, Jagadish C., Chae, Young Chan, Vaira, Valentina, Rivadeneira, Dayana B., Faversani, Alice, Rampini, Paolo, Kossenkov, Andrew V., Aird, Katherine M., Zhang, Rugang, Webster, Marie R., Weeraratna, Ashani T., Bosari, Silvano, Languino, Lucia R., Altieri, Dario C.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2015
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507184/
https://ncbi.nlm.nih.gov/pubmed/26124089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500722112
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