Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells

Class 2 CRISPR-Cas systems, such as Cas9 and Cas12, have been widely applied for targeting DNA sequences in eukaryotic genomes. However, class I CRISPR-Cas systems, which represent about 90% of all CRISPR systems in nature, remain largely unexplored for genome engineering applications. Here, we show...

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Publicado no:Nat Biotechnol
Main Authors: Pickar-Oliver, Adrian, Black, Joshua B., Lewis, Mae M., Mutchnick, Kevin J., Klann, Tyler S., Gilcrest, Kylie A., Sitton, Madeleine J., Nelson, Christopher E., Barrera, Alejandro, Bartelt, Luke C., Reddy, Timothy E., Beisel, Chase L., Barrangou, Rodolphe, Gersbach, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893126/
https://ncbi.nlm.nih.gov/pubmed/31548729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0235-7
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