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Identifying and visualizing functional PAM diversity across CRISPR-Cas systems

CRISPR-Cas adaptive immune systems in prokaryotes boast a diversity of protein families and mechanisms of action, where most systems rely on protospacer-adjacent motifs (PAMs) for DNA target recognition. Here, we developed an in vivo, positive, and tunable screen termed PAM-SCANR (PAM screen achieve...

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Publicat a:Mol Cell
Autors principals: Leenay, Ryan T., Maksimchuk, Kenneth R., Slotkowski, Rebecca A., Agrawal, Roma N., Gomaa, Ahmed A., Briner, Alexandra E., Barrangou, Rodolphe, Beisel, Chase L.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826307/
https://ncbi.nlm.nih.gov/pubmed/27041224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.02.031
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