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Transcription-induced formation of extrachromosomal DNA during yeast ageing

Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid and extensive gene copy number variation and is implicated in the pathology of cancer and ageing. Here, we demonstrate that yeast aged under environmental copper accumulate high levels of eccDNA containing the co...

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Bibliografski detalji
Izdano u:PLoS Biol
Glavni autori: Hull, Ryan M., King, Michelle, Pizza, Grazia, Krueger, Felix, Vergara, Xabier, Houseley, Jonathan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890164/
https://ncbi.nlm.nih.gov/pubmed/31794573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000471
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