Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae

Circular DNA can arise from all parts of eukaryotic chromosomes. In yeast, circular ribosomal DNA (rDNA) accumulates dramatically as cells age, however little is known about the accumulation of other chromosome-derived circles or the contribution of such circles to genetic variation in aged cells. W...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Prada-Luengo, Iñigo, Møller, Henrik D, Henriksen, Rasmus A, Gao, Qian, Larsen, Camilla Eggert, Alizadeh, Sefa, Maretty, Lasse, Houseley, Jonathan, Regenberg, Birgitte
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Genomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430651/
https://ncbi.nlm.nih.gov/pubmed/32609810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa545
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