Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption

Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs) obtained from Vav1-deficient (Vav1(−/−)) and...

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Veröffentlicht in:BMB Rep
Hauptverfasser: Jang, Jin Sun, Kang, In Soon, Cha, Young-Nam, Lee, Zang Hee, Dinauer, Mary C, Kim, Young-June, Kim, Chaekyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Society for Biochemistry and Molecular Biology 2019
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889896/
https://ncbi.nlm.nih.gov/pubmed/31072447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2019.52.11.013
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