Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells

BACKGROUND & AIMS: Porphyrias are caused by porphyrin accumulation resulting from defects in the heme biosynthetic pathway that typically lead to photosensitivity and possible end-stage liver disease with an increased risk of hepatocellular carcinoma. Our aims were to study the mechanism of porp...

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Bibliographic Details
Published in:Cell Mol Gastroenterol Hepatol
Main Authors: Maitra, Dhiman, Carter, Eric L., Richardson, Rani, Rittié, Laure, Basrur, Venkatesha, Zhang, Haoming, Nesvizhskii, Alexey I., Osawa, Yoichi, Wolf, Matthew W., Ragsdale, Stephen W., Lehnert, Nicolai, Herrmann, Harald, Omary, M. Bishr
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889786/
https://ncbi.nlm.nih.gov/pubmed/31173894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.05.010
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