Lamin aggregation is an early sensor of porphyria-induced liver injury

Oxidative liver injury during steatohepatitis results in aggregation and transglutaminase-2 (TG2)-mediated crosslinking of the keratin cytoplasmic intermediate filament proteins (IFs) to form Mallory-Denk body (MDB) inclusions. The effect of liver injury on lamin nuclear IFs is unknown, though lamin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Singla, Amika, Griggs, Nicholas W., Kwan, Raymond, Snider, Natasha T., Maitra, Dhiman, Ernst, Stephen A., Herrmann, Harald, Omary, M. Bishr
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711202/
https://ncbi.nlm.nih.gov/pubmed/23641075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.123026
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