Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2

Epoxyeicosatrienoic acids (EETs) are formed from the metabolism of arachidonic acid by cytochrome P450s. EETs promote angiogenesis linked to tumor growth in various cancer models that is attenuated in vivo by cyclooxygenase 2 (COX-2) inhibitors. This study further defines a role for COX-2 in mediati...

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Udgivet i:J Lipid Res
Main Authors: Rand, Amy A., Rajamani, Anita, Kodani, Sean D., Harris, Todd R., Schlatt, Lukas, Barnych, Bodgan, Passerini, Anthony G., Hammock, Bruce D.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889709/
https://ncbi.nlm.nih.gov/pubmed/31641036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M094219
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