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Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids
Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway are angiogenic, inducing cancer tumor growth. A previous study showed that inhibiting soluble epoxide...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5410821/ https://ncbi.nlm.nih.gov/pubmed/28396419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616893114 |
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