Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids

Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway are angiogenic, inducing cancer tumor growth. A previous study showed that inhibiting soluble epoxide...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Rand, Amy A., Barnych, Bogdan, Morisseau, Christophe, Cajka, Tomas, Lee, Kin Sing Stephen, Panigrahy, Dipak, Hammock, Bruce D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410821/
https://ncbi.nlm.nih.gov/pubmed/28396419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616893114
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