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Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids

Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway are angiogenic, inducing cancer tumor growth. A previous study showed that inhibiting soluble epoxide...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rand, Amy A., Barnych, Bogdan, Morisseau, Christophe, Cajka, Tomas, Lee, Kin Sing Stephen, Panigrahy, Dipak, Hammock, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410821/
https://ncbi.nlm.nih.gov/pubmed/28396419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616893114
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