Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids

Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway are angiogenic, inducing cancer tumor growth. A previous study showed that inhibiting soluble epoxide...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Rand, Amy A., Barnych, Bogdan, Morisseau, Christophe, Cajka, Tomas, Lee, Kin Sing Stephen, Panigrahy, Dipak, Hammock, Bruce D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410821/
https://ncbi.nlm.nih.gov/pubmed/28396419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616893114
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