Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids

Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway are angiogenic, inducing cancer tumor growth. A previous study showed that inhibiting soluble epoxide...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Rand, Amy A., Barnych, Bogdan, Morisseau, Christophe, Cajka, Tomas, Lee, Kin Sing Stephen, Panigrahy, Dipak, Hammock, Bruce D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410821/
https://ncbi.nlm.nih.gov/pubmed/28396419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616893114
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