Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer

BACKGROUND: Tumours rapidly ferment glucose to lactic acid even in the presence of oxygen, and coupling high glycolysis with poor perfusion leads to extracellular acidification. We hypothesise that acidity, independent from lactate, can augment the pro-tumour phenotype of macrophages. METHODS: We an...

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Publicat a:Br J Cancer
Autors principals: El-Kenawi, Asmaa, Gatenbee, Chandler, Robertson-Tessi, Mark, Bravo, Rafael, Dhillon, Jasreman, Balagurunathan, Yoganand, Berglund, Anders, Vishvakarma, Naveen, Ibrahim-Hashim, Arig, Choi, Jung, Luddy, Kimberly, Gatenby, Robert, Pilon-Thomas, Shari, Anderson, Alexander, Ruffell, Brian, Gillies, Robert
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889319/
https://ncbi.nlm.nih.gov/pubmed/31417189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0542-2
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