Intermittent Hypoxia Selects for Genotypes and Phenotypes That Increase Survival, Invasion, and Therapy Resistance

Hypoxia in tumors correlates with greater risk of metastases, increased invasiveness, and resistance to systemic and radiation therapy. The evolutionary dynamics that links specific adaptations to hypoxia with these observed tumor properties have not been well investigated. While some tumor populati...

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Udgivet i:PLoS One
Main Authors: Verduzco, Daniel, Lloyd, Mark, Xu, Liping, Ibrahim-Hashim, Arig, Balagurunathan, Yoganand, Gatenby, Robert A., Gillies, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374837/
https://ncbi.nlm.nih.gov/pubmed/25811878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120958
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