Acidity generated by the tumor microenvironment drives local invasion

The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive growth and metastasis. The hypothesis that acid mediates invasion proposes that H+ diffuses from the proximal tumor microenvironment into adjace...

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Main Authors: Estrella, Veronica, Chen, Tingan, Lloyd, Mark, Wojtkowiak, Jonathan, Cornnell, Heather H., Ibrahim-Hashim, Arig, Bailey, Kate, Balagurunathan, Yoganand, Rothberg, Jennifer M., Sloane, Bonnie F., Johnson, Joseph, Gatenby, Robert A, Gillies, Robert J
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594450/
https://ncbi.nlm.nih.gov/pubmed/23288510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2796
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