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Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice

PURPOSE: Hypoxia and acidosis develop in in situ tumors as cellular expansion increases the diffusion distance of substrates and metabolites from blood vessels deep to the basement membrane. Prior studies of breast and cervical cancer revealed that cellular adaptation to microenvironmental hypoxia a...

詳細記述

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書誌詳細
主要な著者: Ibrahim-Hashim, Arig, Cornnell, Heather H., Abrahams, Dominique, Lloyd, Mark, Bui, Marilyn, Gillies, Robert J., Gatenby, Robert A.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694604/
https://ncbi.nlm.nih.gov/pubmed/22704445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2012.03.113
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