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Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice
PURPOSE: Hypoxia and acidosis develop in in situ tumors as cellular expansion increases the diffusion distance of substrates and metabolites from blood vessels deep to the basement membrane. Prior studies of breast and cervical cancer revealed that cellular adaptation to microenvironmental hypoxia a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3694604/ https://ncbi.nlm.nih.gov/pubmed/22704445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2012.03.113 |
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