Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice

PURPOSE: Hypoxia and acidosis develop in in situ tumors as cellular expansion increases the diffusion distance of substrates and metabolites from blood vessels deep to the basement membrane. Prior studies of breast and cervical cancer revealed that cellular adaptation to microenvironmental hypoxia a...

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Bibliografiske detaljer
Main Authors: Ibrahim-Hashim, Arig, Cornnell, Heather H., Abrahams, Dominique, Lloyd, Mark, Bui, Marilyn, Gillies, Robert J., Gatenby, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694604/
https://ncbi.nlm.nih.gov/pubmed/22704445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2012.03.113
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