Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer

BACKGROUND: Tumours rapidly ferment glucose to lactic acid even in the presence of oxygen, and coupling high glycolysis with poor perfusion leads to extracellular acidification. We hypothesise that acidity, independent from lactate, can augment the pro-tumour phenotype of macrophages. METHODS: We an...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: El-Kenawi, Asmaa, Gatenbee, Chandler, Robertson-Tessi, Mark, Bravo, Rafael, Dhillon, Jasreman, Balagurunathan, Yoganand, Berglund, Anders, Vishvakarma, Naveen, Ibrahim-Hashim, Arig, Choi, Jung, Luddy, Kimberly, Gatenby, Robert, Pilon-Thomas, Shari, Anderson, Alexander, Ruffell, Brian, Gillies, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889319/
https://ncbi.nlm.nih.gov/pubmed/31417189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0542-2
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