A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

BACKGROUND: Cancer arises through accumulation of somatically acquired genetic mutations. An important question is to delineate the temporal order of somatic mutations during carcinogenesis, which contributes to better understanding of cancer biology and facilitates identification of new therapeutic...

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Detaylı Bibliyografya
Yayımlandı:BMC Bioinformatics
Asıl Yazarlar: Wang, Menghan, Yu, Tianxin, Liu, Jinpeng, Chen, Li, Stromberg, Arnold J., Villano, John L., Arnold, Susanne M., Liu, Chunming, Wang, Chi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2019
Konular:
Methodology Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889196/
https://ncbi.nlm.nih.gov/pubmed/31791231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-3218-2
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