A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

BACKGROUND: Cancer arises through accumulation of somatically acquired genetic mutations. An important question is to delineate the temporal order of somatic mutations during carcinogenesis, which contributes to better understanding of cancer biology and facilitates identification of new therapeutic...

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Publicat a:BMC Bioinformatics
Autors principals: Wang, Menghan, Yu, Tianxin, Liu, Jinpeng, Chen, Li, Stromberg, Arnold J., Villano, John L., Arnold, Susanne M., Liu, Chunming, Wang, Chi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Methodology Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889196/
https://ncbi.nlm.nih.gov/pubmed/31791231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-3218-2
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