Leveraging functional annotation to identify genes associated with complex diseases

To increase statistical power to identify genes associated with complex traits, a number of transcriptome-wide association study (TWAS) methods have been proposed using gene expression as a mediating trait linking genetic variations and diseases. These methods first predict expression levels based o...

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Udgivet i:PLoS Comput Biol
Main Authors: Liu, Wei, Li, Mo, Zhang, Wenfeng, Zhou, Geyu, Wu, Xing, Wang, Jiawei, Lu, Qiongshi, Zhao, Hongyu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660930/
https://ncbi.nlm.nih.gov/pubmed/33137096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008315
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