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Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction

Accurate prediction of disease risk based on genetic factors is an important goal in human genetics research and precision medicine. Advanced prediction models will lead to more effective disease prevention and treatment strategies. Despite the identification of thousands of disease-associated genet...

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Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Hu, Yiming, Lu, Qiongshi, Liu, Wei, Zhang, Yuhua, Li, Mo, Zhao, Hongyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482506/
https://ncbi.nlm.nih.gov/pubmed/28598966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006836
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