A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

BACKGROUND: Cancer arises through accumulation of somatically acquired genetic mutations. An important question is to delineate the temporal order of somatic mutations during carcinogenesis, which contributes to better understanding of cancer biology and facilitates identification of new therapeutic...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Wang, Menghan, Yu, Tianxin, Liu, Jinpeng, Chen, Li, Stromberg, Arnold J., Villano, John L., Arnold, Susanne M., Liu, Chunming, Wang, Chi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889196/
https://ncbi.nlm.nih.gov/pubmed/31791231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-3218-2
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