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Activation and regulation of H2B-Ubiquitin-dependent histone methyltransferases

Covalent modifications of histone proteins regulate a wide variety of cellular processes. Methylation of histone H3K79 and H3K4 is associated with active transcription and is catalyzed by Dot1L and Set1, respectively. Both Dot1L and Set1 are activated by prior ubiquitination of histone H2B on K120 i...

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Bibliographic Details
Published in:Curr Opin Struct Biol
Main Authors: Worden, Evan J., Wolberger, Cynthia
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888998/
https://ncbi.nlm.nih.gov/pubmed/31229920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2019.05.009
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