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Mechanism of cross-talk between H2B ubiquitination and H3 methylation by Dot1L
Methylation of histone H3 K79 by Dot1L is a hallmark of actively transcribed genes that depends on monoubiquitination of H2B K120 (H2B-Ub), and is an example of histone modification cross-talk that is conserved from yeast to humans. We report here cryo-EM structures of Dot1L bound to ubiquitinated n...
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| 出版年: | Cell |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6498860/ https://ncbi.nlm.nih.gov/pubmed/30765112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.02.002 |
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