Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by monoubiquitination of the C-terminus of histone H2B (...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: van Welsem, Tibor, Korthout, Tessy, Ekkebus, Reggy, Morais, Dominique, Molenaar, Thom M, van Harten, Kirsten, Poramba-Liyanage, Deepani W, Sun, Su Ming, Lenstra, Tineke L, Srivas, Rohith, Ideker, Trey, Holstege, Frank C P, van Attikum, Haico, El Oualid, Farid, Ovaa, Huib, Stulemeijer, Iris J E, Vlaming, Hanneke, van Leeuwen, Fred
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Gene regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265471/
https://ncbi.nlm.nih.gov/pubmed/30203048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky801
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