Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by monoubiquitination of the C-terminus of histone H2B (...

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書目詳細資料
發表在:Nucleic Acids Res
Main Authors: van Welsem, Tibor, Korthout, Tessy, Ekkebus, Reggy, Morais, Dominique, Molenaar, Thom M, van Harten, Kirsten, Poramba-Liyanage, Deepani W, Sun, Su Ming, Lenstra, Tineke L, Srivas, Rohith, Ideker, Trey, Holstege, Frank C P, van Attikum, Haico, El Oualid, Farid, Ovaa, Huib, Stulemeijer, Iris J E, Vlaming, Hanneke, van Leeuwen, Fred
格式: Artigo
語言:Inglês
出版: Oxford University Press 2018
主題:
Gene regulation, Chromatin and Epigenetics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265471/
https://ncbi.nlm.nih.gov/pubmed/30203048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky801
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