Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by monoubiquitination of the C-terminus of histone H2B (...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: van Welsem, Tibor, Korthout, Tessy, Ekkebus, Reggy, Morais, Dominique, Molenaar, Thom M, van Harten, Kirsten, Poramba-Liyanage, Deepani W, Sun, Su Ming, Lenstra, Tineke L, Srivas, Rohith, Ideker, Trey, Holstege, Frank C P, van Attikum, Haico, El Oualid, Farid, Ovaa, Huib, Stulemeijer, Iris J E, Vlaming, Hanneke, van Leeuwen, Fred
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265471/
https://ncbi.nlm.nih.gov/pubmed/30203048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky801
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