Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1

Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, systematic screening for epigenetic regulators is challenging and often relies on laborious assays or indirect reporter read-outs. Here we descri...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Vlaming, Hanneke, Molenaar, Thom M, van Welsem, Tibor, Poramba-Liyanage, Deepani W, Smith, Desiree E, Velds, Arno, Hoekman, Liesbeth, Korthout, Tessy, Hendriks, Sjoerd, Maarten Altelaar, AF, van Leeuwen, Fred
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179194/
https://ncbi.nlm.nih.gov/pubmed/27922451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18919
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