AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage

Enhanced vascular permeability in the lungs can lead to pulmonary edema, impaired gas exchange, and ultimately respiratory failure. While oxygen delivery, mechanical ventilation, and pressure-reducing medications help alleviate these symptoms, they do not treat the underlying disease. Mechanical act...

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Bibliographic Details
Published in:APL Bioeng
Main Authors: Li, Juan, Wen, Amy M., Potla, Ratnakar, Benshirim, Ezekiel, Seebarran, Ariel, Benz, Maximilian A., Henry, Olivier Y. F., Matthews, Benjamin D., Prantil-Baun, Rachelle, Gilpin, Sarah E., Levy, Oren, Ingber, Donald E.
Format: Artigo
Language:Inglês
Published: AIP Publishing LLC 2019
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887658/
https://ncbi.nlm.nih.gov/pubmed/31803860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.5122967
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