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Interplay between affinity and valency in effector cell degranulation: a model system with polcalcin allergens and human patient-derived IgE antibodies
An allergic reaction is rapidly generated when allergens bind and crosslink immunoglobulin E bound to its receptor FcεRI on effector cells, resulting in cell degranulation and release of pro-inflammatory mediators. The extent of effector cell activation is linked to allergen affinity, oligomeric sta...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6887533/ https://ncbi.nlm.nih.gov/pubmed/31462504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900509 |
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