Comparative reactivity of human IgE to cynomolgus monkey and human effector cells and effects on IgE effector cell potency

Background: Due to genetic similarities with humans, primates of the macaque genus such as the cynomolgus monkey are often chosen as models for toxicology studies of antibody therapies. IgE therapeutics in development depend upon engagement with the FcεRI and FcεRII receptors on immune effector cell...

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Main Authors: Saul, Louise, Josephs, Debra H, Cutler, Keith, Bradwell, Andrew, Karagiannis, Panagiotis, Selkirk, Chris, Gould, Hannah J, Jones, Paul, Spicer, James F, Karagiannis, Sophia N
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984339/
https://ncbi.nlm.nih.gov/pubmed/24492303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27828
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