Anti-folate receptor-α IgE but not IgG recruits macrophages to attack tumors via TNF-α/MCP-1 signaling

IgE antibodies are key mediators of anti-parasitic immune responses, but their potential for cancer treatment via antibody-directed cell-mediated cytotoxicity (ADCC) has been little studied. Recently, tumor antigen-specific IgEs were reported to restrict cancer cell growth by engaging high-affinity...

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I publikationen:Cancer Res
Huvudupphovsmän: Josephs, Debra H, Bax, Heather J, Dodev, Tihomir, Georgouli, Mirella, Nakamura, Mano, Pellizzari, Giulia, Saul, Louise, Karagiannis, Panagiotis, Cheung, Anthony, Herraiz, Cecilia, Ilieva, Kristina M, Correa, Isabel, Fittall, Matthew, Crescioli, Silvia, Gazinska, Patrycja, Woodman, Natalie, Mele, Silvia, Chiaruttini, Giulia, Gilbert, Amy E, Koers, Alexander, Bracher, Marguerite, Selkirk, Christopher, Lentfer, Heike, Barton, Claire, Lever, Elliott, Muirhead, Gareth, Tsoka, Sophia, Canevari, Silvana, Figini, Mariangela, Montes, Ana, Downes, Noel, Dombrowicz, David, Corrigan, Christopher J, Beavil, Andrew J, Nestle, Frank O, Jones, Paul S, Gould, Hannah J, Sanz-Moreno, Victoria, Blower, Philip J, Spicer, James F, Karagiannis, Sophia N
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173310/
https://ncbi.nlm.nih.gov/pubmed/28096174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1829
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