Anti-folate receptor-α IgE but not IgG recruits macrophages to attack tumors via TNF-α/MCP-1 signaling

IgE antibodies are key mediators of anti-parasitic immune responses, but their potential for cancer treatment via antibody-directed cell-mediated cytotoxicity (ADCC) has been little studied. Recently, tumor antigen-specific IgEs were reported to restrict cancer cell growth by engaging high-affinity...

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Pubblicato in:Cancer Res
Autori principali: Josephs, Debra H, Bax, Heather J, Dodev, Tihomir, Georgouli, Mirella, Nakamura, Mano, Pellizzari, Giulia, Saul, Louise, Karagiannis, Panagiotis, Cheung, Anthony, Herraiz, Cecilia, Ilieva, Kristina M, Correa, Isabel, Fittall, Matthew, Crescioli, Silvia, Gazinska, Patrycja, Woodman, Natalie, Mele, Silvia, Chiaruttini, Giulia, Gilbert, Amy E, Koers, Alexander, Bracher, Marguerite, Selkirk, Christopher, Lentfer, Heike, Barton, Claire, Lever, Elliott, Muirhead, Gareth, Tsoka, Sophia, Canevari, Silvana, Figini, Mariangela, Montes, Ana, Downes, Noel, Dombrowicz, David, Corrigan, Christopher J, Beavil, Andrew J, Nestle, Frank O, Jones, Paul S, Gould, Hannah J, Sanz-Moreno, Victoria, Blower, Philip J, Spicer, James F, Karagiannis, Sophia N
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173310/
https://ncbi.nlm.nih.gov/pubmed/28096174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1829
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