Comparative reactivity of human IgE to cynomolgus monkey and human effector cells and effects on IgE effector cell potency

Background: Due to genetic similarities with humans, primates of the macaque genus such as the cynomolgus monkey are often chosen as models for toxicology studies of antibody therapies. IgE therapeutics in development depend upon engagement with the FcεRI and FcεRII receptors on immune effector cell...

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Bibliografske podrobnosti
Main Authors: Saul, Louise, Josephs, Debra H, Cutler, Keith, Bradwell, Andrew, Karagiannis, Panagiotis, Selkirk, Chris, Gould, Hannah J, Jones, Paul, Spicer, James F, Karagiannis, Sophia N
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2014
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984339/
https://ncbi.nlm.nih.gov/pubmed/24492303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27828
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